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Replicon-Based Screening Assay for HCV

 

Description

This invention provides replicon-based screening assay for HCV. Transgenic mammalian cell host is developed to provide screening assay for pharmacologic inhibitors of HCV RNA replication. This invention has advantages over conventional screening assay based recombinant protease or polymerase of HCV. Since the host cell express HCV proteins whose level can be detected by replicon-based screening assay, leading to the development of highly accurate diagnostic test for HCV infection.

Benefits and Applications

Providing a diagnostic test for HCV infection

Screening assay to identify lead compounds against HCV

Intellectual Property Status

Patent pending (KR, 2 applications)

Related Publication

RNA, 2003, 9:599-606

Mole. Cell. Biol. 2003, 23:708-720


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