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Enhanced Targeting of Drug Delivery with Nucleoside Based Phospholipids

 

Description

This invention provides phospholipids constituting nucleoside backbone such as adenine, guanine, cytosine, thymine, and uracil, etc. and the production method thereof. In addition, the invention provides a synthetic method of liposome which can recognize and adhere to each other through complementary binding between bases therein.

Benefits and Applications

Providing phospholipids which have high heat stability of melting point of 200 deg. C, and are soluble in organic solvent and stable under weak acid or base conditions

High-yield synthesis of phospholipids

Providing liposome prepared from phospholipids whose backbone is composed of bases

Providing a preparation method of liposome that has adjustable range in size from 50 to 150 nm for drug delivery system

Demonstrating more efficient drug entrapment than in glycerol-based phospholipids

Can be applied for developing a drug delivery system which can recognize liposome molecule and interact with a specific cell through complementary binding of bases in liposome

Intellectual Property Status

Patent pending (KR)

Related Publication

In press


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