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Phosphoramidites for Synthesis of Oligodeoxynucleotide

 

Description

This invention provides phosphoramidite compounds useful for the synthesis of commercially available DNA variants, and its production method. According to the invention, phosphoramidite compounds introduced with various functional groups such as 1,3-butandiol, benzyglycolate, lithocholic acid, etc., can be synthesized and can be used for synthesizing the oligodeoxynucleotides useful for various objects.

Benefits and Applications

Providing a synthetic method for phosphoramidite by using 1,3-butandiol, benzylglycolate, and lithocholic acid, etc.

Can be applied for developing gene-based therapeutics with increased cell permeability which is introduced with nonpolar lithocholic alcohol

Can be used for the synthesis of oligodeoxynucleotide dendrimer introduced with various nucleic acid sequences, and the diagnostic agent thereof

Can be applied for the synthesis of oligodeoxynucleotide wtih various nanostructure

Developing a synthetic method for dendrimer with specific functional groups

Intellectual Property Status

Patent pending (PCT)

Related Publication

Synlett., 2003, 1838

Nucleosides, Nucleotides & Nucleic Acids., 2003, 22, 2003

Current Medicinal Chem., 2003, 10, 1973


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