rIL-12 Encapsulated with Biodegradable Microspheres as a Vaccine Adjuvant
This invention provides a component to enhance vaccine-specific T helper 1 immune responses by delivery of encapsulated rIL-12 with biodegradable microspheres as a molecular vaccine adjuvant. As a strategy to achieve the persistence of IL-12 in vivo, we designed rIL-12-encapsulated biodegradable microspheres, and the co-delivery of these microspheres induces stronger and longer-lasting T helper 1 immune responses at a great degree than IL-12 DNA or unmodified rIL-12 protein.
Benefits and Applications
Efficient induction of T helper 1 and CTL immune responses required for protection from HBV, TB, and influenza etc.
Efficient induction of antibody responses
Vaccine adjuvant to enhance the efficacy of conventional subunit vaccines such as HBV or influenza vaccines
Intellectual Property Status
Patent pending (KR)
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