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Molecular Transporters Mediating Cell Membrane Crossing

 

Description

This invention provides inositol-based molecular transporters that can effectively mediate the plasma membrane and nuclear cell crossing for a variety of drugs. The transporters have the scaffold units having requisite number of attachment sites, and attachment of guanidine functionality through suitable linkers. In vitro model (COS7 and RAW264.7) for these arginine-rich molecular transporters demonstrates a high permeability through cytoplasm and the nuclear membrane, compared to that of arginine-poor intermediate.

Benefits and Applications

Providing broad class of inositol-based derivatives as a scaffold for molecular transporters

Providing a way to design optimal inositol derivatives to enhance a permeability through cell membrane

Providing inositol composition for delivering a therapeutic or diagnostic agent

Potential application: drug delivery system (ex. the blood brain barrier & gut absorption)

Intellectual Property Status

Patent pending (PCT)

Related Publication

Bioorg. Med. Chem. Lett., 2003, 13, 2981-2984

Bioorg. Med. Chem. Lett., 2004, 14, 2499-2503


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