Description

This technology provides the improved immobilization method that makes the binding force measurement between single molecules such as DNA-DNA using enhanced AFM tip. When AFM tip is modified with size-controlled dendrons, the tethered single strand is allowed to move around in solution enough to find its complementary part when the tip approaches the surface. Since single DNA molecule is attached to the apex of the AFM tip, precise measurement single DNA-DNA molecule interaction. This approach can also be applied to direct measurement of numerous biological processes such as DNA-protein and protein-receptor interaction.

Benefits and Applications

Providing appropriate spacing control of DNA strands in AFM tip for improved recognition efficiency of complementary DNA-DNA or DNA-RNA

Providing method for precise measurement of binding force between complementary DNA strands

Can be easily extended for measurement of protein-ligand or protein-protein interaction force

Can be applied for the development of carbon or metal nanotube

Intellectual Property Status

Patent pending (US)

Related Publication

In preparation

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